Curcumin and Pancreatic Cancer: A Research and Clinical Update
نویسندگان
چکیده
Pancreatic cancer is currently one of the most deadly types of cancer. Poor patient prognosis is linked to the lack of effective early detection techniques and emerging resistance to current therapeutic strategies. Thus, current research efforts are focusing on overcoming drug resistance. One branch of this field of study is the use of natural compounds to combat pancreatic cancer and drug resistance. Curcumin, a turmeric derivative, is one such compound that has been shown to have potent anti-cancer properties in the context of pancreatic cancer. However, curcumin’s poor bioavailability limits its clinical utility. Multiple approaches have been taken to overcome this problem, including curcumin modifications, curcumin combination therapy with other natural and synthetic therapeutic agents and the use of nano-formulations. This review is intended to provide a compendium of the cutting-edge investigations related to preclinical and clinical uses of curcumin, including its analogues and nano-formulations, in the context of pancreatic cancer. Journal of Nature and Science, 1(6):e124, 2015
منابع مشابه
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Pancreatic cancer is one of the most lethal malignancies and the fourth leading cause of cancer-related deaths worldwide, because of its aggressive and highly metastatic ability even in its early stages. Cancer-associated fibroblasts (CAFs) have been reported to be vital to pancreatic cancer progression via regulating tumorigenesis and metastasis. Studies have shown that CAFs also mediate epith...
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